CYP2D6 and CYP2C19 variants directly affect how psychiatric medications are metabolized. Delano's experience of adverse effects and difficult discontinuation is, for many patients, a pharmacogenomic story — the wrong drug, wrong dose, or difficult taper driven by metabolizer status never checked.
A memoir of 14 years inside the American psychiatric system — multiple diagnoses, cascading medications beginning in her teens, and an eventual decision to taper off all psychiatric drugs. Raises legitimate, evidence-supported concerns about diagnostic overreach and polypharmacy in psychiatry, while documenting what psychiatric drug withdrawal actually looks like.
One of the most-discussed memoirs in the growing conversation about psychiatric overdiagnosis and polypharmacy.
These peer-reviewed studies connect to the core ideas in this book. Each result has been scored for reliability.
Covers the research on how specific nutrients — omega-3s, B vitamins, fat-soluble vitamins — affect brain and metabolic function. Directly relevant to FADS1 and BCMO1 variant research on nutrient conversion efficiency.
Two researchers present the evidence for micronutrient support — including methylated B vitamins — in mental health. Directly relevant to MTHFR compound het and the connection between folate processing and neurotransmitter synthesis.
Sports psychology meets physiology. Covers the mental architecture of athletic performance — how to train the brain alongside the body. Particularly relevant for COMT ValVal athletes who perform differently under competition pressure versus low-stakes training.