MTHFR, COMT, BDNF, FKBP5, and the serotonin transporter variants all affect neurotransmitter production — a process that is downstream of mitochondrial energy production. Palmer's framework connects your genomic neurochemistry variants to the energy systems that power them.
A Harvard psychiatrist proposes that mental disorders are fundamentally metabolic disorders of the brain — driven by mitochondrial dysfunction — and argues metabolic interventions (diet, especially ketogenic approaches, exercise) should be part of psychiatric treatment. One of the most important paradigm-shifting books in mental health research of the last decade.
One of the most talked-about paradigm shifts in psychiatry in the last decade: the mitochondrial hypothesis of mental illness.
These peer-reviewed studies connect to the core ideas in this book. Each result has been scored for reliability.
Covers the research on how specific nutrients — omega-3s, B vitamins, fat-soluble vitamins — affect brain and metabolic function. Directly relevant to FADS1 and BCMO1 variant research on nutrient conversion efficiency.
Two researchers present the evidence for micronutrient support — including methylated B vitamins — in mental health. Directly relevant to MTHFR compound het and the connection between folate processing and neurotransmitter synthesis.
Sports psychology meets physiology. Covers the mental architecture of athletic performance — how to train the brain alongside the body. Particularly relevant for COMT ValVal athletes who perform differently under competition pressure versus low-stakes training.