Sinclair's information theory of aging covers sirtuins, NAD+, mTOR, and the epigenetic clock. Directly relevant to SIRT1 TT and FOXO3 TT pathway research — explaining the biological mechanisms these variants affect and the interventions being studied.
Sinclair (a Harvard geneticist) presents the "Information Theory of Aging" — that aging is driven by loss of epigenetic information — and reviews the interventions his lab has studied: sirtuin activators (resveratrol, NMN), rapamycin, senolytics, caloric restriction, and cold/heat exposure. Ends with a forecast of where the field is heading.
The book that made "NAD+" and "sirtuins" household words in the biohacking community and drew both major popular attention and academic pushback to the geroscience field.
These peer-reviewed studies connect to the core ideas in this book. Each result has been scored for reliability.
The most comprehensive evidence-grounded longevity framework currently in print. Covers the primary causes of early death, and how exercise, nutrition, sleep, and emotional health address each one. Relevant to FOXO3, SIRT1, OBFC1, and cardiovascular genetics research.
Written by the Nobel Prize winner who discovered telomerase. Covers how telomere length connects to biological aging and what lifestyle factors the research shows protect telomere integrity. Essential reading for OBFC1 AA and TERT variant carriers.
Covers the gut-longevity connection with a focus on microbiome diversity and dietary fiber. The gut-longevity axis discussion is relevant to NOD2 and FUT2 research on how gut immune function affects systemic health over time.